Cys-loop ligand-gated chloride channels in Dorsal Unpaired Median neurons of Locusta
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چکیده
Daniel Janssen, Christian Derst, Jean-Michel Rigo, and Emmy Van Kerkhove 3 4 5 1 Centre of environmental sciences, Department of Physiology, Hasselt University and 6 transnationale Universiteit Limburg, Agoralaan, Diepenbeek, 3590, Belgium 7 2 Biomedical research institute, Hasselt University and transnationale Universiteit Limburg, 8 Agoralaan, Diepenbeek, 3590, Belgium 9 3 Institute for Integrative Neuro-anatomy, AG Prof. Veh, Philippstr. 12, 10115 Berlin, Germany 10 11 12 13 14 *Corresponding author: Daniel Janssen, D.V.M., PhD-student 15 ∫ contributed equally 16 Phone: ++32 (0) 11 26 92 56 17 Fax: ++32 (0) 11 26 92 99 18 E-mail: [email protected] 19 20 21 22 23 24 25 26 27 28
منابع مشابه
Cys-loop ligand-gated chloride channels in dorsal unpaired median neurons of Locusta migratoria.
In insects, inhibitory neurotransmission is generally associated with members of the cys-loop ligand-gated anion channels, such as the glutamate-gated chloride channel (GluCl), the GABA-gated chloride channels (GABACl), and the histamine-gated chloride channels (HisCl). These ionotropic receptors are considered established target sites for the development of insecticides, and therefore it is ne...
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Together with type A GABA and strychnine-sensitive glycine receptors, glutamate-gated chloride channels (GluCl) are members of the Cys-loop family of ionotropic receptors, which mediate fast inhibitory neurotransmission. To date, GluCls are found in invertebrates only and therefore represent potential specific targets for insecticides, such as ivermectin and fipronil. In this study, we identifi...
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A primary cell culture was developed for efferent dorsal unpaired median (DUM) neurons of the locust. The isolated somata were able to generate Tetrodotoxin (TTX)-sensitive action potentials in vitro. The alpha-like scorpion toxin BmK M1, from the Asian scorpion Buthus martensi Karsch, prolonged the duration of the action potential up to 50 times. To investigate the mechanism of action of BmK M...
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RDL receptors are invertebrate members of the Cys-loop family of ligand-gated ion channels. They are GABA (gamma-aminobutyric acid)-activated chloride-selective receptors that are closely related to their vertebrate orthologues, the GABA(A) receptors, as well as other Cys-loop receptors such as the ionotropic glycine, nicotinic acetylcholine and 5-HT(3) receptors. RDL receptors are widely expre...
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Ivermectin acts as a positive allosteric regulator of several ligand-gated channels including the glutamate-gated chloride channel (GluCl), gamma aminobutyric acid type-A receptor, glycine receptor, neuronal alpha7-nicotinic receptor and purinergic P2X4 receptor. In most of the ivermectin-sensitive channels, the effects of ivermectin include the potentiation of agonist-induced currents at low c...
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تاریخ انتشار 2010